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Received medical training and graduated with summa cum laude at 1st Faculty of Medicine, Charles University, Prague in 1994.
After graduation he worked as junior physician at 3rd Internal Department of General University Hospital of 1st Faculty of Medicine in Prague, initially in the field of metabolism, but later he converted to cardiology. In 2001 he received board certification in cardiology and PhD degree equivalent, with thesis about endothelial dysfunction and risk factors and atherosclerosis. Later became involved in clinical research (with Dr. D. Wichterle) in pathophysiology of cardiovascular regulations in hypertension and heart failure.

In 2002-2005 he spent 3 years as post-doc fellow in the labs of David Kass, Johns Hopkins Hospital and of Edward D. Lakatta, NIA-NIH in Baltimore, MD, USA.

Since 2005 he works in the Institute of Clinical end Experimental Medicine- IKEM as Research deputy director of Cardiology department.

In 2012-2013 he was Fulbright visiting professor at Mayo Clinic working with Dr. Barry A. Borlaug.

In 2013 he was appointed as Associated professor at 1st Faculty of Medicine, Charles University in Prague.



In 2022 was appointed as full professor of internal medicine at 1st Faculty of Medicine, Charles University in Prague.

Since 2013 he is medical director of heart failure service at IKEM.

Besides his clinical duties, he leads interdisciplinary research program focused on hemodynamic and metabolic aspects of heart failure pathophysiology, collaborating with Czech Academy of Sciences, Charles University, BIOCEV, Harvard University and Mayo Clinic. This research is funded by Czech Science foundation (GACR) and Agency for Health research (AZV). He is active member of Heart Failure Association of ESC, Czech Cardiology society, American heart Association and ISHLT.

Dr. Melenovsky published 166 peer-reviewed research papers that were cited >20 000x, h-index: 48 (WOS). Hide profil